Pharmacokinetic studies on oral administration of aspirn (ASA) in the middle-aged and aged persons and clinical investigations of its dosage selectivity for treatment of cerbral thrombus

It has been proved in recent years that small dosage of aspirin（ASA）has high selectivity to inhibit blood platelet aggregation,so that how to select an optimal dosage for the treatnent of ischenic cerbral blood vessel disease is an imperative task in clinical practice. This article reported pharmacokinetic studies on the administration of ASA in rabbit and the healthy subjects and investigstion on the effects of small dosage of oral administration ASA on arachidonic acid（AA）and adenosyl diphosphate（ADP）levels in 10 aged patients.The results indicated that small dosage oral adminstration of ASA had also marked inhibition to AA and ADP levels even after twenty-four hours.It is.therefore,suggested that it may be reasonable to give ASA in the dese of 0.1gm daily in the freatment of cerebral vasalatr disease in aged patients.