Morphological study of war wound urethral stricture reconstructed with biodegradable urethral stent with autologous urethral epithelial cells

Objective: To compare the biocompatibility properties and histological analysis of a new mesh biodegradable stent with autologous urethral epithelial cells to the spiral biodegradable stent in a war wound（or traumatic） rabbit urethral strictures model.Methods: The animal urethral epithelial cells were cultured by biopsy in vitro and seeded to the outer layer of the mesh biodegradable stent.The 18 male New Zealand white rabbits were anaesthetized and the two stents inserted into the urethra.The rabbits were killed at different sample time to analyse the effects.Results: The cultured cells adhere to fibers and growing very well.Conclusion: The mesh biodegradable stent with autologous urethral epithelial cells seem to have more advantages and function well in a war wound（or traumatic） rabbit urethral strictures model.