Protection of breviscapine against lipid peroxidation damage of liver

Objective: To explor the effect of breviscapine（Bre） on lipid peroxidation in hepatic ischemia-reperfusion injury（HIRI）.Methods: The HIRI model was used.Sixteen rabbits were randomly divided into control group（n=8） and Bre group（n=8）.The superoxide dismutase（SOD） activity,malondialdehyde（MDA） content in hepatic tissue were observed,and obsvered the cell structure of the liver microscope at reperfusion 60 min.Results: The SOD activity and MDA content of Bre group,as compared with control group,showed significant differences（P＜0.01）.The change of the cell structure in Bre group is lighter than in the control group.Conclusion: Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.liver;reperfusion injury;superoxide dismutase;malondialdehyde;drugs,chinese nerbal