The Effects of Serum from Patients with IgA Nephropathy on Cultured Glomerular Mesangial Cells

In this paper. the effects of serum from 38 patients with IgA nephropathy on cultured gloumerular mesangial cells in vitro were studied. the IgA-CIC, IgG-CIC and IgM-CIC in the serum were measured by using ELISA. The results were summarized as follows: 1. the ~3H-TdR uptake into mesangial cells was markedly enhanced （P＜0.01） by the serum of IgA nephropathy on culture medium, and the increment was closely related to the severity of glomerular pathological changes (r=0.429; 2. the levels of IgA-CIC and IgG-CIC increased in the serum of patients with IgA nephropathy than those in normal controls （P＜0.05）; and 3. there was a close relationship between the amount of urinary protein and the degree of renal pathological changes （r=0.616）.