Study on the expression of c-myc gene product and HBxAg in human hepatocellu-lar carcinoma

Immunohistochemical technique（ABC） was used to detect the expression of p62^c-myc and HBxAg inparaffin embedded tissues of human hepatocellular carcinoma（HCC）and corresponding adjacent non-tumor-ous liver tissues （NT）from 48 patients.The results showed that the positive rates of p62^c-myc were 83.3%（40/48）in HCC and 89.6%（43/48）in NT.The positive rates of HBxAgwere 93.8%（45/48）in HCC andNT,The significant positive correlation was noticed between p62^c-myc and HBxAg in HCC（P＜0.05）,givingfurther evidence that HBxAg might function as a transactivator in the course of c-myc proto-oncogene activa-tion,These observations suggest that over expression of c-myc gene may be closely associated with hepato-carcinogensis.