Effect of lidocaine on serum reactive oxygen species in patients undergoing off-pump coronary artery bypass graft

Objective To study the effect of lidocaine on serum reactive oxygen species（ROS） in patients undergoing off-pump coronary artery bypass graft（OPCAB）. Methods Thirty patients（23 males,7 females） undergoing OPCAB were randomly divided into control group（group C） and lidocaine group（group L）,15 in each group.Patients in group L were anesthetized with intravenous lidocaine（2mg/kg） followed by infusion of lidocaine 2mg/（kg·h） till the end of operation.Patients in group C were given the same volume of 0.9% sodium chloride at the same amount.Blood samples were taken from the internal jugular vein before operation（T₁）,immediately after heparinization（T₂）,immediately after operation（T₃） and 24h after operation（T₄）.Superoxide dismutase（SOD） and malindialdehyde（MDA） were detected by spectrometry. Results No significant difference was found in SOD at different time points between the two groups（P＞0.05）.No significant change of MDA was observed at different time points in group L.The MDA level was significantly higher in group C at T₄ than at T₁（7.4 nmol/ml±2.3nmol/ml vs 3.7nmol/ml±1.1nmol/ml,P＜0.01）.However,a significant difference was found in MDA at T₄ between the two groups（7.4nmol/ml±2.3nmol/ml vs 4.7nmol/ml±1.3nmol/ml,P＜0.05）.The stay time of group L in ICU and hospital was significantly shorter than that of group C（P＜0.05）. Conclusion Lidocaine can inhibit the release of ROS in patients undergoing OPCAB.