Regularity for development of CKD in middle-aged and old patients with type 2 diabetes

Objective: To evaluate the risk factors for development of chronic kidney disease（CKD） in middle-aged and old patients with type 2 diabetes and to explore the prognosis and development rule of CKD. Methods: One hundred and twelve patients with type 2 diabetes over the age of 50 years,who were admitted twice to the Chinese PLA General Hospital between 2000 and 2008,were studied.The patients were divided into 4 groups according to their serum creatinine（normal,high） and urine protein（normal,albuminuria） levels.Serum creatinine and GFR levels were meausred and the incidence of cerebral infarction,ESRD and coronary heart disease was calculated.The risk factors and rule of serum creatinine occurrence were studied by correlation analysis.Data were analyzed using CHISS. Results: There was a positive correlation between TP,UA,TG,LP（a）,ACR,UAE,DR,CI,smoke and SCr progression.There was a negative correlation between SCr,BUN,P,Mg and SCr progression（P＜0.05）.Stepwise regression analysis showed that there was a visible linear correlation between ACR,Cr,CA15-3 and SCr progression. Conclusion: UA,TG,LP（a）,SCr,BUN,CA15-3,urine protein,smoke and the course of hypertension contribute to the progression of CKD.Patients with high serum creatinine and micro-albuminuria levels are at a higher CKD stage with worse prognosis.Micro-albuminuria,SCr and CA15-3 are the risk fasters for CKD.