Effects of adenosine receptor antagonist on isoflurane-induced myocardial protection in isolated rat hearts

Objective: To determine whether isoflurane induced myocardial protection is mediated by adenosine receptor subtype A 1.Methods: Five groups （n=8） of isolated rat hearts were studied in the Langendorff apparatus The hearts were subjected to 30min global ischemia and 120min reperfusion DP, EDP, LV+dp/dt max and LV dp/dt min were recorded and analyzed after administrating isoflurane and （or） adenosine receptor antagonist （DPCPX）.Results: Isoflurane significantly decreased EDP and improved the recoveries of DP, LV+dp/dt max and LV dp/dt min during reperfusion compared with control groups（P＜0 05） DPCPX administrated before or after the global ischemia couldn′t attenuate the protection of isoflurane （P ＞00 05）.Conclusion: Isoflurane enhances the post ischemic functional recovery of isolated rat heart and A 1 receptors are not involved in isoflurane induced myocardial protection