Antibiotic resistance of six major pathogens related with hospital acquired nosocomial bloodstream infection and mortality of such patients

Objective To investigate the antibiotic resistance of 6 major pathogens related with hospital acquired nosocomial bloodstream infection and the mortality of such patients. Methods Clinical data about 492 cases of hospital acquired bloodstream infection with Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Enterococcus faecium, and Entercoccus faecalis, retrospectively, in our hospital from January 2006 to December 2008 were analyzed. Results The crude mortality of patients with hospital acquired nosocomial bloodstream infection with the 6 pathogens was 22.29%, 23.44%, 28.28%, 28.30%, 36.25%, and 38.46%, respectively. Extended broad spectrum beta lactamase-producing strains, methicillin-resistant staphylococcus aureus strains, imipenem-resistant strains, and multidrug-resistant strains accounted for 50.96% of Escherichia coli, 62.63% of Staphulococcus aureus, 23.44% of Pseudomonas aeruginos, and 54.72% of Acinetobacter baumannii, respectively. Enterococcus faecium and Enterococcus faecalis accounted for 71.25% and 56.41% of gentamicin-resistant strains, respectively. Conclusion The mortality is the highest in patients with hospital acquired nosocomial bloodstream infection with Enterococcus faecalis. The mortality is higher in patients with hospital acquired nosocomial bloodstream infection with methicillin-resistant staphylococcus aureus and carbapenem-resistant Acinetobacter baumannii than in those with hospital acquired nosocomial bloodstream infection with methicillin- susceptible staphylococcus aureus and non-carbapenem -resistant strains.