The variation of function and morphology of Leydig cells in testis of diabetic rats

Objective:To investigate the influence of diabeteson the function and morphology of Leydig cells.Methods:The model of diabetic rat was induced by STZ. Two months later, the diabetic rats were sacrificed. Serum testosterone level and hCG binding site of testicular tissue were measured, the morphology of Leydig cells was observed with light and electron microscopy.Results:The serum testosterone level and hCG binding sites of diabetic rats were significantly lower than those of normal rats （P＜0.01）. The morphologocal changes of Leydig cells consisted of cell shrinkage severe mitochondrion and endoplasmic reticulum vacuolization.Conclusions:Diabetes could impaire the function and structure of Leydig cells.