Study on the rational perioperative application of cephazoline in the elderly

The changes of pharmacodynamics of cephazoline 1.5gm. iv, in a series of 7 patients with a mean age of 71 years old were studied perioperatively. All of the parameters of the results were compared with lhosein patients younger than 60 years. The distribution phase of half life of the agent （t _1/2 α） and the elimination phase of half of it （t _1/2 β） were significantly prolonged; namely its distribution and elimination were both lower than those in the younger patients.The gorge concentration in the blood with administration of cephazoline 1.5gm. iv. Q8hrs. was constantly maintained in 8 μg/ml or more; and proximal half of the results were exceed 8 μg/ml, when cephazoline administered 1.5gm iv. Q12hrs.Therefore, the principle of administration of such antibiotics must know well about the dose, times and limit properly. Both schemes could be selected in the elderly patients according to their general condition.