Changes of TXB2 and 6-keto-PGF1α and effects of compound anisodine I during experimental choroidal ischemia

TXB2 and 6-keto-PGF1α were measured during choroidal ischemia caused by resecting partial poste-rior cilliary arteries in rabbits, The effects of compound anisodine I（CAI）were also investigated. The results showed that TXB2 and 6-keto-PGF1αwere temporally increased at one hour post-ischemia,and 6-keto-PGF1αwas decreased at 24 h post-ischemia while TXB2 was still high and leading an increased ratio of TXB2/6-keto-PGF1α CA-1 could increase the level of 6-keto-PGF1α,Our results indicate that the changes of TXB2 and 6-ke-to-PGF1α occur during choroidal ischemia,and that CA-1 improves the rnicrocirculation at ischemic areas and may regulate vascular tone.