Effect of propofol on prostacyclin and thromboxane during hemorrhagic shock and resuscitation in monkeys

Objective: To investigate the effect of propofol on the plasma concentrations of prostacyclin(PGI₂) and thromboxane A₂(TXA₂). Methods: Twelve monkeys with hemorrhagic shock were devided randomly into two groups.The monkeys in propofol group received propofol at plasma concentration 8mg/L by target control infusion,while monkeys in control group received normal saline in the same.Venous blood were collected to determine plasma prostacyclin (PGI₂) and thromboxaneA₂(TXA₂)concentrations by radio-immunoassay before bleeding, 2 hours after hemorrhagic shock and 2 hours after resuscitation. （Results: Compared） with control group’s,the TXA₂ level of propofol group was significantly lower at 2 hours after resuscitation（（P=0.0001））, and the ratio of PGI₂/TXA₂ of propofol group was higher（P=0.0001）. Conclusion: These findings indicate that propofol can decrease the plasma concentration of TXA₂ in hemorrhagic shock and resuscitation monkeys,which may be beneficial to control the development of hemorrhagic shock.