Effect of detemir and neutral protamine hagedorn on blood glucose level in type 2 diabetes patients: A comparative study

Objective To compare the effects of detemir and neutral protamine hagedorn（NPH） injection in combination with oral anti-diabetes drugs（OAD） on blood glucose level in type 2 diabetes patients with a poor response to OAD. Methods Thirty-six type 2 diabetes patients were randomized into two groups,which were treated with detemir+ OAD and NPH+ OAD for 20 weeks,respectively.HbA1C,FBG and glucose levels were monitored with a continuous glucose monitoring system（CGMS） before and after treatment. Results At week 20,the HbA1c decreased from 9.19% to 8.72 % in detemir+ OAD group and from 7.81% to 7.39% in NPH+OAD group,respectively,while the FBG decreased from 11.7mmol/L to 6.59mmol/L in detemir + OAD group and from 11.0mmol/L to 6.29mmol/L in NPH+OAD group,respectively（P＜0.05）.No significant difference was found in HbA1c and FBG between the two groups before and after treatment.The coefficient of variation（CV） for blood glucose was significantly lower after treatment than before treatment in detemir+ OAD and NPH+ OAD groups.The average body weight gain in two groups was（-1.22±1.84）kg and（2.19±2.81）kg,respectively（P＜0.05）.The incidence rate of hypoglycemia was significantly lower in detemir+ OAD group than in NPH+OAD group and no hypoglycemia occurred in night. Conclusion The effect of detemir+ OAD and NPH + OAD on blood glucose in patients with type 2 diabetes is similar.However,detemir+ OAD is advantageous over NPH +OAD in control of body weight gain.