Removal of beta 2 microglobulin in different blood purification modalities for uremia

Objective: To investigate the best way to remove uremic middle molecules through comparison between different blood purification modalities.Methods: Fourty-one hemodialysed patients were enrolled by the beta 2 microgloubulin screening（＞5 mg/L） from January to May 2007 in our center and divided randomly into five groups（HD,CVVH,CVVHDF,HP and HPHD,7,10,9,7,8 cases respectively）.Blood was sampled before and after treatment.Decrement and clearance rate of beta 2 microglobulin were calculated and statistically analysed.Results: The beta 2 microglubulin decrement in five groups was（-6.7±6.2）%,（41.8±12.0）%,（22.1±7.6）%,（30.1±3.4）%,（10.7±8.5）% respectively.Total removal was（-3.3±3.0）mg,（23.5±8.6）mg,（14.6±6.3）mg,（17.7±2.4）mg,（7.1±5.6）mg respectively.CVVH ranked first.The clearance rates of beta 2 microglobulin were（-0.8±0.7）mg/h,（3.7±1.3）mg/h,（2.4±1.1）mg/h,（8.9±1.2）mg/h,（1.8±1.4）mg/h respectively.HP ranked the highest,HD ranked the lowest.Conclusion: The five modalities showed different results in beta 2 microglobulin remove.We should select proper modality to fulfill clinical requirement.