Effect of VNS on amino-acid transmitters in brain and behavior of epileptic rat

Objective: To invstigate the antiepileptic effect and change of amino-acid transmitters in frontal lobe of epileptic rat by VNS.Motheds: To make rat model of epilepsy and give VNS by A or B or C stimulators,and mensure the amino-acid changs in frontal lobe of thoses rats and behaviors change in 1hour,24 hours or 1 week after.Results: Gly and GABA are the key amino-acids in VNS effection,there were high GABA and low Glu/GABA in frontal lobe of rat 1h after A and B model VNS,and 24h after B model stimulation,seizures reduces markedly only in 24 hours in B3 groups.Conclusions: VNS,by medium and high grade homemade stimulator,can reduce seizure in 24h following change of GABA.amino acid neurotransmitters;epilepsy;rat;vagus nerve;tissue therapy