Small molecule compounds targeting bcl-2 inhibit angiogenesis in cornea

Objective To study the inhibitory effect of Z24,a small molecule compound targeting bcl-2 protein,on angiogenesis in cornea of rats. Methods Thirty Wistar rats were randomly divided into treatment group and control group with 15 rats in each group.A model of angiogenesis in cornea of rats was induced by placing sutures in the cornea.Rats in treatment group received Z24 suspension（80mg/kg）while rats in control group were given a solution containing no Z24,once a day for 7 days.Angiogenesis in cornea of 8 rats of each group was observed and histology change was monitored in the other rats. Results The area of angiogenesis in cornea was significantly smaller in treatment group than in control group 7 days after placement of sutures（P＜0.05）. Conclusion Systemic administration of Z24 can delay angiogenesis in cornea of rats.