Trace elements and hepatocellular carcinoma

The trace elements including Fe, Zn, Cu and Mn were quantitively analyzed in the tissues of the carcinoma and pericarcinoma from HCC by atomic absorption spectrophotometry. The pathological morphology of the liver was also studied. Conclusion: Fe, Zn and Mn contents in the carcinoma tissue are lower than in the normal and pericarcinoma tissue. The mean Cu content had no difference among them. There was no correlation between the contents the serum and the tissues. There was significant decrease of Fe, Gu, Zn and Mn contents in clear cell carcinoma, cell necrosis and fatty change; the base membrane formation of sinusoid and decrease in cell organs. which is the cause or effec for HCC, the mechanism of trace element deserves further study.