The gender difference in the association of blood lipid with coronary heart disease

Objective:The blood levels of lipid and apolipoprotein were determined in 403 subjects for the sake of evaluating the gender differene in the association of blood lipid with coronary heart disease.Methods:In the total subjects studied, there were 233 cases with coronary heart disease （CHD group） and 170 healthy individuals （control group）. Gender subgroups were further divided in each group. Results:（1） Blood levels of TC, TG, LDL-C and Lp（a）were significantly higher,and HDL-C level was lower in both female and male CHD groups compared with the corresponding gender control group. （2） In comparison with males, the blood levels of TC,LDL-C and HDL-C were significantly higher in females in both CHD cases and healthy controls, but the difference in the ratio of TC to HDL-C was not significant. （3）The indices such as HDL-C,TC, hypertension, age and apoB were the independent predictors for the risk of CHD in males, while only HDL-C and hypertension were the independent risk factors for CHD in females.Conclusion:The gender difference of blood lipids mades the association of lipied with CHD somewhat different in females from in males. In the evaluation of CHD risk in females, special attention should be paid to blood HDL-C level, because it is usually higher than that in males.