Dawn phenomenon in NIDDM 10 patients

To assess the dawn phenomenon and its frequency in NIDDM patients on conventional therapy, 10 patients （6 males, 4 females with age of 41.7±5.7 year） were studied. Hourly blood samples were taken from 24:00 to 8:00 h for BG, F, GH, GG and INS. ACTH was measured at 24: 00, 03:00, 05:00 and 08:00 h respectively. If we defined the dawn phenomenon as a rise in early morning BG of＞1.0mmol/l, then 6/10 patients in the present group exhibited this phenomenon. Thus the dawn phenomenon occurs commonly in NIDDM patients treated with conventional therapy. This study suggest that the deficiency of insulin and the increased level of couterregulatory hormone-F may pay a role in pathogenesis of the dawn phenomenon in NIDDM patients.