Correlation between karyotype and fluconazole susceptibility of Candida Albicans

Objective: To analyze the correlation between karyotype and fluconazole susceptibility of Candida albicans.Methods: 14 isolates of C.albicans were evaluated for molecular relatedness by pulsed-field gel electrophoresis of chromosome-size DNA molecules.Minimal inhibitory concentration（MIC） of fluconazole against C.albicans was determined by ATB FUNGUS2 INT;Isolates were identified by MicroScanWalkAway96 RY-ID.Results: Karyotype revealed a total of 9 different genotypes among 14 isolates of C.albicans from 11 patients.Among the 14 isolates,only two isolates were resistant to fluconazole（＞128 μg·mL^-1）.The rest 12 isolates were all sensitive to fluconazole（＜8 μg·mL^-1）.Conclusion: In our study,there is no distinct difference of karyotype between fluconazole-resistant isolates and fluconazole-sensitive isolates.