Serum tumor markers of metastatic hepatic carcinoma and primary liver cancer

Objective To study the role of serum tumor markers（TM） in differential diagnosis of metastatic hepatic carcinoma and primary liver cancer. Methods Serum TM levels were measured by electrochemiluminescence technique in 174 cases of metastatic hepatic carcinoma and 101 cases of primary liver cancer. Results There was a statistical difference in positive rate of AFP and CEA between metastatic hepatic carcinoma and primary liver cancer（P＜0.01）. The positive rate of CEA in the colon,rectum,pancreas was higher than that of other markers（P＜0.01）, while the positive rate of CA125 and CA199 in pancreas,mammary glands,ovary were higher than that of the other markers（P＜0.01）. The positive rate of combined detection was higher than that of single detection. Conclusion AFP and CEA are better serum TM for differential diagnosis of metastatic hepatic carcinoma and primary liver cancer. Changes in characteristics of serum TM are different in metastatic hepatic carcinoma of different origins. Combined detection can better monitor the curative effect on metastatic hepatic carcinoma and primary liver cancer.