Dehydroandrostenedione secreting adrenal adenoma in an adult female

A 22-year-old female with primary amenorrhea and virilization was found to have dehydroandrostenedione secreting adrenocortical adenoma, which was identified by GC-5970B series mass selective detecter. To our knowledge this may be the first published case involving measurement of androgen contents in the adrenal adenoma, The serum testosterone and urinary 17 ketosteroid levels were high. There was no response to dexamethasone suppression test. The tumor was localized at left adrenal by GT scan. Microscopic examination showed typical features of adrenocortical adenoma with no evidence of Leydig cells. Postoperatively, hirsutism regressed with regular monthly menstruation. Tracing the source of unreliable or false results, these tumors are usually rather large. Therefore, CT scanning of the adrenal glands is recommended in all patients with suspected androgen secreting tumor.