A study of gene polymorphism of the angiotensin-converting enzyme,angiotensinogen and angiotensin receptor type 1 in pilots

Objective: To understand gene polymorphism of the angiotensin-converting enzyme,angiotensinogen and angiotensin receptor type 1 in pilots,and to investigate the association between gene polymorphism and the perfomance of the pilots.Methods: 253 pilots and 236 healthy control subjects were genotyped for the insertion/delation（I/D） polymorphism of the（angiotensin）-converting enzyme（ACE） gene,M235T polymorphism of angiotensinogen（AGT） gene and A1166C polymorphism of angiotensin receptor type 1（ATR1） gene by the polymerase chain reaction（PCR）.Results: It was showed the genotype II and I allele frequency of ACE were significantly higher in pilots（45.06% and 0.67） than that in healthy subjects（31.36% and（0.52））.No difference between the two groups was found for the AGT and ATR1 genotypes.Conclusion: It is suggested that I gene of ACE may play a role in performance of the pilots.peptidyl-dipeptidase A;angiotensinogen;receptors,angiotensin;aviator