Expression of Ki-67,P53 and YB-1 in breast cancer tissue and its clinical significance

Objective To study the expression of Ki-67,P53 and YB-1 in breast cancer tissue and its clinical significance.Methods Immunohistochemistry was used to detect expression of YB-1 in tissues from 180 breast cancer patients admitted to Chinese PLA General Hospital from January 2000 to December 2004.Immunohistochemistry staining of Ki-67 and P53 from these patients was retrospectively collected.Correlation between expression of YB-1,Ki-67,P53 and clinical pathological features of the patients was analyzed.Results The expression rate of Ki-67,P53 and YB-1 in tissue from breast cancer patients was 73.9%,35.0% and 38.3%,respectively.The expression of Ki-67 was positively correlated with the lymph node metastasis,degree of differentiation,vascular invasion,Her-2 and negatively correlated with the ER and PR（P＜0.05）.The expression of P53 was positively correlated with the degree of differentiation and Her-2（P＜0.05）.The expression of YB-1 was positively correlated with Her-2 and negatively correlated with the ER and PR（P＜0.05）.A positive correlation was observed between the expressions of Ki-67,P53 and YB-1.Conclusion Expression of Ki-67,P53 and YB-1 in breast cancer tissue is correlated with the poor pathological features of such patients and can thus be regarded as an important prognostic indicator of breast cancer patients.