Expression and clinical significance of hypoxia inducible factor-1α in gliomas

Objective:To research the expression of hypoxia inducible factor-1α（HIF-lα） and its relationship with the pathological grades in gliomas.To evaluate the relationships of HIF-lα expression with VEGF and microvessel density（MVD） among the three and to investigate their association with pathological grades、angiogenesis of human gliomas.Methods: The expression of HIF-1α、VEGF and as well as the proteins associated with microvessel density in the gliomas were studied with SP immunohistochemical staining.Results: The positive expression of HIF-1α in human gliomas of 54 cases was 61.1%,which was related with the histological grade of tumor.The expression of HIF-1α was positively correlated with VEGF（χ²=4.02,P＜0.05） and MVD（t=3.22,P＜0.05）.Conclusion: HIF-1α correlates positively to histological grade and angiogenesis.The expressions of HIF-1α can be used to assess the prognosis in glioma patients.