Value of new impaired fasting glucose cut-point in middle-aged patients with pre-diabetes

Objective To assess the effectiveness of impaired fasting glucose（IFG） cut-point in elderly patients with pre-diabetes. Methods Data about elderly patients with NGT and IGR diagnosed by 75g OGTT test during Beijing epidemiological survey in June 2004 were analyzed.The glucose metabolism status（NGT,IFG1,IFG2,IGT,IFG/IGT） was defined following the 2003 ADA diagnostic criteria.Effect of down-regulated IFG cut-point on IGR components was assessed.IGR accompanying abnormal metabolism and other diseases classified with the new IFG cut-point was analyzed. Results According to the 1999 WHO and 2003 ADA diagnostic criteria,the component ratio of different glucose metabolism states was 72.2% vs 64.4% for NGT group,1.9% vs 9.7% for IFG group,23.0% vs 17.3% for IGT group,and 3.0% vs 8.6% for IFG/IGT group,respectively.The ratio of hypertension,dyslipidemia,micro-albuminuria,and cardiovascular disease was significantly higher in IFG1 group accompanying hypertension than in NGT group（36.1% vs 30.9%,46.2% vs 38.2%,13.3% vs 6.1%,and 9.6% vs 6.0%,P＜0.05）. Conclusion Compared with the 1999 WHO criteria,the 2003 ADA criteria can expand the ratio of IFG and IFG/IGT patients.The ratio of patients with 5.6≤FPG ＜6.1mmo1/L accompanying metabolic disorders and other diseases is significantly higher than that of those with normal glucose metabolism.From the point of early prevention and control of the disease,the down-regulated IFG cut-point has its rationality.