Protective effect of Ginkgo biloba extract on myocardial ischemia in rabbits

Objective To observe the protective effect of Ginkgo biloba extract on rabbit myocardial ischemia reperfusion injury. Methods Forty rabbits were randomly divided into control group,model group,and three Ginkgo biloba extract decoction groups（8 in each group）.Rabbits in control and model groups were given normal saline. Rabbits in three Ginkgo biloba extract decoction groups were given Ginkgo biloba extract at different doses（20mg/kg,50mg/kg,100mg/kg）. A model of myocardial ischemia reperfusion injury was established by ligating the branch of left coronary artery. Serum phosphokinase（CPK）, malonic aldehyde（MDA）, superoxide dismutase（SOD）, and creatine kinase（CK） levels in myocardium tissue were measured. The shape of ST segment on ECG was observed. Results The serum levels of CPK and MDA were significantly lower while the serum levels of CK and SOD were significantly higher in three Ginkgo biloba extract decoction groups than in the other two group（P＜0.01）. The ST segment on ECG was elevated in model group,but showed a decreasing trend in three Ginkgo biloba extract decoction groups. Conclusion Ginkgo biloba extract has a stronger protective effect on myocardial ischemia reperfusion injury.