Change of serum noradrenalin levels in cirrhosis swine with portal hypertension after DSRS

Objective: To observe the change in the level of plasma noradrenaline（NA） in blood vessels,including splenic vein（SV）,portal vein（PV）,inferior vena cava（IVC） in cirrhosis porcine with portal hypertension after distal splenorenal shunts（DSRS）.Methods: Animal model of portal hypertensive（PHT）porcine was induced by CCl₄/ethanol,operation of distal splenorenal shunts（DSRS） was performed,free portal pressure（FPP）,Splenic vein pressure（SVP）,left renal vein pressureowere investigated,High Pressure Liquid chromatography（HPLC） was used to measure plasma concentration of NA in PV,SV and IVC.Results: After the formation of PHT,FPP,SVP and concentration of NA in SV,PV,IVC were significantly increased,Concentration of NA in SV was significantly higher than in PV.After DSRS was performed,left renal vein pressure increased（P＜0.05）,SV pressure were significantly decreased.Concentration of NA in SV,PV,IVC and FPP had no significant changes（P＞0.05）.Concentration of NA in SV was significantly higher than in PV before and after DSRS（P＜0.05）.Conclusion: Significant metabolic disorders of NA in porcine cirrhosis with PHT are obvious,which may play an important role in the pathogenesis of portal hypertension.