Changes of eight free fat acids in bile of rats during total parenteral nutrition

Objective:To investigate the changes of 8 free fatty acids（FFA） in bile of rats during total parenteral nutrition（TPN）.Methods: Measuring the FFAs in bile by gas chromotography Results:（1）Bile percentage concentrations of FFAs of C_14∶0,C_16∶0,C_18∶0,and C_20∶4,in fat-free TPN group were remarkably higher than that of controls and lipid-TPN groups, but with decreased C_18∶2 and C_18∶3,in fat-free TPN group; （2）No difference was found between controls and lipid-TPN groups in percentage concentrations of FFA in bile except that C_18∶1 was higher than that of controls.Conclusion:Lipid-TPN may reduce the degree of bile FFA change during TPN, and thus play an important role in the prevention of TPN-indued biliary complications.