Clinical study of prognostic implication of CK in exertional heat stroke

Objective: To analyze the accuracy of CK value as a prognostic indicator in exertional heat stroke（EHS） patients.Methods: We retrospectively analyzed 11 cases of EHS in 6 military hospitals from Sep 1995 to Aug 2007.In terms of prognosis,the 11 patients were divided into two groups: D group（those who died,n=4）and S group（those who survived and were discharged,n=7）.We compared CK values in two groups at 0 h、 12 h、 24 h、 36 h、 48 h、 60 h、 72 h after admission and plotted the receiver-operating characteristic plots（ROC） curve at 48 hour to analyze the accuracy of CK value as a prognostic indicator in the initial stage of EHS.Results: The CK values continued to increase in D group at all time intervals after admission,the CK values were stable and generally decreased after a mild increase,the values between the two groups had significant deviation at 48 h、 60 h、 72 h after admission（P＜0.05）.CK ROC had an AUC of 0.893 at 48 h.Conclusion: The trends of CK in dead patients and survival patients are significantly different,the former is significantly higher than that of the latter.CK can be a useful indicator of the prognosis of EHS in the initial stage of EHS（48 h）.