An initial study on the characteristics of humoral immunity of patients with infectious atypical pneumonia

Objective: to investigate the characteristics of humoral immunity of patients with SARS.Methods: The levels of the specific IgG and IgM in the serum of patients with SARS were detected by ELISA.Results: The specific IgG in serum of patients with SARS increased continuously during hospitalization，The maximal rate of positive samples was 77.3%；The levels of specific IgM increased continuously in the first three weeks during in-hospital，then the maximum of IgM was found in the third week，the positive rate were 60%， and decreased quickly during the for th week.The occurrence of the specific positive IgM was earlier than that of IgG by one week.Conclution: There were specific IgG antibody in serum of all patients with SARS and the specific IgM were only found in serum of 70%～80% patients with SARS.The generation time and the basic characteristics of the specific antibody of patients with SARS were similar to that of other infectious diseases.