Malignant lymphoma transformed from lymphoid interstitial pneumonia:a case report and literature review

Objective To investigate the clinical feature,diagnosis,treatment and the malignant transformation of lymphoid interstitial pneumonia（LIP）. Methods The clinical data of one case with LIP malignant transformation admitted in our hospital was retrospectively analyzed and the related literatures were reviewed. Results The 62-year-old female patient was admitted to our hospital because of fatigue,progressive exertional dyspnoea and occasional left lung pain for 6 months.She was diagnosed with LIP according to pathological findings,and was found to have malignant transformation at follow-up examination 1 year later.After surgery and chemotherapy,the patient had been stable both radiographically and clinically for 5 years. Conclusion LIP is a rare disease and we have hardly ever seen its malignant transformation.High awareness of LIP malignant transformation and proper consideration in the right clinical context are prerequisites for early diagnosis,and a combination of multiple treatment modalities should be considered as a feasible treatment regimen.