Epidermal growth factor receptor mutation in lung adenocarcinoma

Objective: To study Somatic mutation of the tyrosine kinase（TK） domain of the epidermal growth factor receptor（EGFR gene） in lung adenocarcinoma patients.Methods: Mutational analysis for EGFR exons 18,19,20 and 21 was performed in 64 patients.Results: Somatic mutations in TK domain of EGFR were identified in 16 of the 64（25%） patients,including 2 cases in exon 18（3.12%）,7 cases in exon 19（10.93%） and 7 cases of in exon 21（10.93%）.Conclusion: EGFR gene mutations is concentrate on 19 and 21 hot sport.The mutation rate of women is higher than that of men.