Risk factors for clopidogrel resistance in patients with coronary artery disease accomapmying hypertension:A logistic regression analysis

Objective To study the risk factors for clopidogrel resistance（CR） in patients with coronary artery disease（CAD） accompanying hypertension（HPT）. Methods Clinical data about 122 patients with CAD accompanying HPT admitted to Department of Cardiology,Chinese PLA General Hospital,from October 2010 to April 2011,were retrospectively analyzed.The patients were divided into CR group and clopidogrel response group according to the inhibition of their platelets（through the way of ADP inhibition rate in mTEG）.The patients were divided into non-response group（NRG） and response group（RG）.The risk factors for clopidogrel response were analyzed by univariate analysis and multivariate stepwise logistic regression analysis. Results Of the 122 patients with CAD accompanying HPT,49 were responsive to clopidogrel,accounting for 40.2%.Univariate analysis showed that 3 variables could influence the response of patients with CAD accompanying HPT to clopidogrel.Multivariate stepwise logistic regression analysis revealed that fasting blood glucose was an independent factor for CR in these patients（β=0.193,P=0.033） and alcohol drinking might be a protective factor for CR（β=-1.175,P=0.051）. Conclusion Fasting blood glucose is closely related with CR and therefore it should actively controlled in patients with CAD accompanying HPT on clopidogrel therapy.