Study on comparison of insulin pump and regular insulin in the treatment of early diabetic nephropathy

Objective:To compare the different effect between continuous subcutaneous insulin injection（CSII） and multiple subcutaneous insulin injection（MSII） on diabetic nephropathy.Methods: 40 cases of early diabetic nephropathy with CSII and 46 cases with MSII were treated in the same period of time.Results: the urinary albumin excretion rate（UAER） of both CSII and MSII group were significantly decreased after treatment.and the β-2 microglobulin（β-2M） were decreased as well.but the UAER and β-2M in CSII group had a more remarkable decrease than that in MSII group.Conclusion: Insulin injection could decrease the urine microalbumine and β-2M of early diabetic nephropathy.and CSII could get a more effective treatment.