Comparision of Antibacterial Activity of IMP/CS and other 6 Anti- microbial Agents Against Clinical lsolates

The minimum inhibitory concentration（MIC） of 7 antimicrobialagents against 215strains of 5 species of clinical isolates were determined by using agar disk dilution method and thesusceptible rates were analyzed. The results showed that all 7 antimicrobial agents exhibited highactivity against most of isolates tested, Among them the IMP/CS had best activity; the susceptiblepercentage of S. aureus, Proteus sp,E. coli,K. pneumonia to the IMP/CS were high up to 97.6 100%;only 17.02%strains of ps aeruginosa were resistant to IMP/CS;2-6 strains of Psaeruginosa and l strains of K. pneumonia were crossresistant to IMP/CS and other antimicrobialagents. The crossresistant percentage of the isolates tested to CPFX and other antimicrobialagents were 2.38-19.05%. The results suggested that IMP/CS may be used in treatment of seriousinfections caused by clinical isolates resistant to other B-lactam antimicrobial agents; the CPFXshould be selected according to the susceptibility test.