Effect of shenlongjiannao capsules on expression of hippocampal proteins in rats with vascular dementia

Objective To study the effect of shenlongjiannao capsules on expression of hippocampal proteins in rats with vascular dementia（VD）. Methods A rat VD model was established by ligating the bilateral common carotid arteries.Thirty rats were randomly divided into model group,shenlongjiannao capsule group and sham operation group.Morris water maze test was performed after the rats had been given shenlongjiannao capsules for 4 weeks and the differences of hippocampal proteins between model group and shenlongjiannao capsule group were analyzed by two-dimensional polyacryalmide gel electrophoresis and ultraflex TOF/TOF mass spectrography. Results Shenlongjiannao capsules could significantly improve the learning and memory ability of model rats.The expression of 7 and 2 proteins was down-regulated and up-regulated,respectively,in shenlongjiannao capsule group compared to that in model group.Eight proteins were identified by ultraflex TOF/TOF mass spectrography. Conclusion Shenlongjiannao capsules can improve the learning and memory ability of rats with VD by regulating the expression of hippocampal proteins.