Research on the human leucocyte antigens(HLA) in 27 patients with congenital dislocation of the hip(CDH)

77 samples for assay of HLA antigens in 27 patients with CDH were investigated and the results were compared with those from normal control determined by our hospital (n=27) and those by PLA 307 hospital (n=78). HLA antisera were offered by Chengdu Central Blood Bank and the microcytotoxic test were used for determination of HLA-A, B, C and DR antigens. our data show statistical difference between CDH and normal control in antigen frequency of HLAB6, DR10 and Cw3. by Fisher's method for calculation of P value, the difference is of statistical significance, HLA-B6 and DR10 being higher than normal control (P＜0.001 and 0.01 respectivelly) and HLA-Cw3 lower than normal control (P＜ 0.05). It is suggested that immunogenetic factors may be responsible, at least partly, for the development of CDH.