Clinical application of 24-hour esophageal and intragastric pH monitering in 100subjects

The changes of esophageal pH rhythm in 32 subjects and intragastric pH in 68 subjccts werere-searched by using 24 hour pH monitering,Compared with healthy subjects,patients with gastroesophageal reflux disease（GERD）had signiflcant differences in total percentage time at pH＜4,supine and upright frac-tion time at pH＜4,number of reflux episodes and the longest reflux time at pH＜4,GERD was demonstrated by using pH monitering in 5 patients with esophageal reflux symptoms but without esophagitis by endoscopy.Monitering of 24 hour intragastric pH showed that the level of median pH,baseline pH,percentage time of pH＜2 were similar in healthy suUects of dlfferent age groups.But the postprandial decline phase and prandial plateau pha:ewere longer in the aged than that in the younger.The value of median pH was lower and accumulated percentage time of pH＜2was longer in patients with duodenal ulcer than that in healthy subjects.It is suggested that the 24 hour pH monitering is an accurate and sensitive mehiod for reflecting of gastroesophageal reflux and intragastric hydrogen ion activity.