Therapeutic effects on homemade sirolimus drug-eluting stent in treatment of in-stent restenosis

Objective: To evaluate the efficiency and safety of homemade sirolimus drug-eluting stent in treatment of in-stent restenosis（ISR） in patients with coronary artery disease.Methods: All 32 patients with ISR and clinical evidence of ischemia had been treated with Firebird stents.Follow-up was done by interview.A proportion of patients were followed up by angiography.Results: All stents were implanted successfully.There were no major complications during the procedure and hospital.Average follow up time was 3-15 months（8.6±2.2）,with a clinical follow-up rate of 93.8% and angiographic follow-up rate of 78.1%.One patient had recurrent angina with an angiographic evidence of the complete occlusion in stent after procedure three months.The possible cause of complete occlusion was the formation of late thrombosis.The patient was death in the third day after the bypass surgery.The major adverse cardiac event（including death,acute myocardial infarction and target lesion revascularization,MACE） rate,the stent thrombosis rate and the restenosis rate of stent was all 3.3%（1/30）.Conclusion: The homemade sirolimus drug-eluting stent implantation is safe and feasible for the treatment of in-stent restenosis in patient with coronary heart disease.