The elevation of plasma calcitonin gene related peptides caused by intestinal ischemia reperfusion in rats

By radioimmunoassay, it was discovered that intestinal ischemia reperfusion caused a 3.5 fold increase of the CGRP in rat plasma, and a 2.2 fold elevation compared with sham group. In pulmonary lavage fluid, the level of CGRP was 39% heigher than that of sham. Intra peritoneal use of phospholipase A 2 or cyclooxgenase inhibitor （TRIF or INDO） caused an increase of CGRP in plasma but decrease in pulmonary lavage fluid. However, CGRP release from normal tissue was promoted by both above drugs in vitro experiment. The observations suggest that intestinal I/R injury may cause increase of plasma CGRP, PLA 2 activation and its metabolites release seem to have some influences on the plasma and pulmonary CGRP levels.