Effects of urokinase on the experimental chronic glomerulosclerosis in rats

An animal model of chronic glomerulosclerosis was induced by 7/8 nephrectomy in Wistar rat.Theresults showed that hemoglobin and plasma albumin were significantly decreased and the blood level of BUN,Cr,cholesterol,triglyceride and urinary protein output were significantly increased in the experimental ratsComputerized quantitative analysis of glomerular area demonstrated that the area of glomerulus, mesangialsclerosis and fibrin-like exudation were significantly increased.The levels of BUN and Cr and proteinuria de-creased significantly after UK treatment.The area of glomerulus,mesangial sclerosis and fibrin-like exudationdecreased significantly in the UK treated group. It is concluded that the renal histological lesion on experimen-tal rats may be improved by treatment with UK.