Adjunct intraperitoneal resuscitation therapy for hemorrhagic shock of rats

Objective To explore the effect of adjunct intraperitoneal resuscitation on hemorrhagic shock（HS） of rats. Methods A HS model of rats was established.Conventional resuscitation（CR） or CR plus adjunct intra-peritoneal resuscitation（IR） was performed when the mean aortic pressure（MAP） remained 40mmHg for 90min to observe the effect of different resuscitation methods on MAP.Three hours after resuscitation, some rats were killed with their ileum mucosa removed to observe its villus morphology under a light microscope.The degree of ileum mucosa injury was evaluated and the effect of different resuscitation methods on survival time of other rats was observed. Results Compared with CR, IR could significantly improve the MAP（P＜0.05）, attenuate the ileum mucosal villus injury（P＜0.01）, prolong the survival time, and decrease the mortality of rats with HS. Conclusion Adjunct intraperitoneal resuscitation therapy can be a more effective way for HS.