Clinical, immunophenotypic and cell cyclic analysis of chronic lymphocytic leukemia（CLL）

15 cases of CLL were immunophenotyped with a panel of monoclonal antibodies. 13 cases BCLL, which was characterized by CD₂0⁺, HLA-Dr⁺, Smlg⁺, CDs⁺and Em⁺. 2 cases were T-CLL, one with Ts phenotype and the other with Dr⁺T-CLL. The ratio of G0+G1 cells in bone marrow of CLL was 91.1±2.3%（76.0±5.1% in controls）, while S+G₂M cells was 8.9±2.3% （23.9± 5.1%in controls）. The ratios of various cyclic cells were similar in bone marrow and in peripheral blood. Prolymphocytoid transformation developed in late stage of 3 CLL patients. The clinical course, cytochemistry and immunologic changes in CLL are also analysed in this paper.