Effect of NO donor SNAP on colibacillus and staphylococcus epidermidis growth in vitro

Objective:To investigate the bacteriostatic effect of NO donor SNAP on colibacillus and staphylococcus epidermidis growth in vitro.Methods: colibacillus and staphylococcus epidermidis were cultured in SNAP with concentrations of 0.5 mmol/L,1 mmol/L,10 mmol/L,25 mmol/L and 50 mmol/L,and were placed in cabinet with 37 ℃ and 45%～60% humidity for 5 houres.Results: SNAP with different concentrations had the effect of bacteriostasis on Staphylococcus epidermidis,SNAP had no bacteriostatic effect on colibacillary.Conclusions:①NO donor-SNAP could release NO on the condition of acidification.②NO donor-SNAP has bacteriostasis effect on staphylococcus epidermidis and colibacillary.However,the bacteriostasis effect of NO donor-SNAP is concentration dependent.