Effect of low dosage La（NO₃）₃ on the defence function of free radical in rats kidney

Objective: To investigate effect of low dosage La（NO₃）₃ on the defence function of free radical in rats kidney.Methods: The activities of Cu-ZNSOD,CAT,LPO and GSH-Px in the rat kidney were studied by means of biochemical measure after rat were given different doses of La（NO₃）₃ for 6 months respectively.Results: The levels of Cu-ZnSOD and CAT in the 10.0 and 20.0 mg/kg of having taken La（NO₃）₃ for 6 months were reduced,but the levels of LPO and GSH-Px were increased.The levels of Cu-ZnSOD and CAT in the 2.0、 0.2 and 0.1 mg/kg of having taken La（NO₃）₃ for 6 months were increased,but the levels of LPO were reduced,the levels of GSH-Px did not obvious difference.Conclusion: The changing about Cu-ZnSOD、 CAT、 GSH-Px and LPO may be related to the dosages.