Effect of TECA bioartificial liver support system on the canines with acute liver failure by partial liver resection

Objective: To evaluate the efficacy and safety of the TECA BALSS in treating ALF canines induced by partial liver resection Methods: 10.ALF canines received BALSS treatments,and 4 ALF canines were treated with BALSS without porcine hepatocytes Blood was perfused through a hollow fiber tube containing 1×10.¹⁰ porcine hepatocytes 5 AlF canines received drugs Each treatment lasted 6 h.Results: ALF canines got beneficial effects with decreased the level of plasma ammonia,ALT,AST,BIL,PT and increase level of PA after BALSS treatment There were no changes in count of lymphocytes,immune proteins （IgA,IgG,IgM） and supplementary （C3,C4） levels after BALSS treatment In contrast,for the ALF canines in non hepatocyte BALSS group and drug group,there were no significant changes in levelsof ammonia,BIL,ALT,AST,BIL,PT and PA ALF canines in BALSS group,non hepatocyte BALSS group and drug group lived respectively an average time of 108.0±12.0.h,（24.0±6.0） h and （20.4±6.4） h,and 3 ALF canines in BALSS group survived.Conclusion: TECA BALSS is efficacious and safe for ALF canines induced by partial liver resection.