A rabbit model of partial growth plate closure

Objective: To develop the rabbit model of peripheral partial growth plate closure.Methods: There are 20 white New-Zealand rabbit with 4-6 weeks old and weighting 1-1.5kg was used as the experimental animals.We resected part of the growth plate on the right lateral condyle on the distal femur;the area is about 45%-50% of the total growth plate.The left side femur was served as the sham operation self-control group.After operation we observed if the osseous bridge will appear and the degree of deformity through gross specimen,radiography and histological methods.Results: 4 months after operation,the femoral length of left were significantly longer than the right,and the angle of the valgus deformity of the left side were significantly smaller than the right side.There is statistically significant difference between the two groups.Conclusion: This is a simple method to make the model of peripheral partial growth plate closure,and the rate of success is very high.growth plate;disease models,animal;animals,laboratory