Effect of the fructose 1,6-bisphosphate preconditioning in the isolated rat myocardium LVEDP MDA and SOD

Objective: To study the effect of the fructose 1,6-bisphosphate in preconditioning on the change of myocardium MDA and SOD in the isolated rat. Methods: The experiments were carried out in the ischemia reperfusion model rats.After 10 min preperfusion with Krebs-Ring(with and without 5mmol·L^-1 FDP) and bicarbonate buffer,ischemia time was 20 min,then followed by 20 min reperfusion with K-R buffer(with and without 5mmol·L^-1 FDP).At the end of each step the concentrations of MDA and SOD were determined on ventricle homogenates from 48 hearts of the rats. Results: Control group shows obviously increase LVEDP in the step of ischemia（P＜0.05）.FDP preconditioning could obviously decrease the concentrations of MDA during reperfusion（P＜0.05）,during ischemia（P＜0.01）,increase SOD versus control（P＜0.01）. Conclusion: FDP preconditioning could enhance the effect of root myocardium to hypoxia and have good protective effect on ischemia reperfusion injury of rats myocardium.